Abstract
A series of potent 1,2-benzothiazine 1,1-dioxide alpha-ketoamide inhibitors of calpain I is described.
MeSH terms
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Animals
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Brain / metabolism
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Calpain / antagonists & inhibitors*
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Cell Line, Tumor
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Cell Membrane Permeability / drug effects
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Cell Membrane Permeability / physiology
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Cell Survival / drug effects
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Humans
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Molecular Structure
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Rats
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Structure-Activity Relationship
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Sulfonamides / pharmacology
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Thiazines / chemical synthesis
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Thiazines / pharmacology*
Substances
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Sulfonamides
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Thiazines
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Calpain